博乐欣与氯丙咪嗪治疗强迫症疗效对照研究

A comparative study of venlafaxine and clomipramine in treatment of obsessive-compulsive disorder

目的探讨博乐欣治疗强迫症的疗效及安全性。方法将45例强迫症患者随机分成博乐欣组(23例)和氯丙咪嗪组(22例)。采用耶鲁布朗强迫量表(Y-Bocs)、副反应量表(TESS)评定,观察8周。结果①博乐欣组与氯丙咪嗪组疗效相似,两组治疗后Y-Bocs评分,博乐欣有效率65.2%,氯丙嗪咪有效率72.7%(P>0.05),差异无统计学意义。②两组病程与疗效呈正相关,病程越短,疗效越好。③两组性别比较,男性治疗效果好于女性。④药物副反应(TESS),博乐欣组比氯丙咪嗪组轻,且为一过性,易于耐受。⑤博乐欣起效快,改善强迫思维优于氯丙咪嗪,缓解强迫行为氯丙咪嗪好于博乐欣。结论博乐欣治疗强迫症有效,强迫思维优于强迫行为,起效时间快,副反应轻微,男性优于女性,病程越短,治疗效果越好。

Objective Observe the effect and security of venlafaxine in obsessive - compulsive disorder （OCD） treating. Methods Forty - five OCD patients were divided into venlafaxine group（23cases） and clomipramine group（22cases）, and they were observed by Y -Bocs and TESS in 8 weeks. Results 1. The effect between two groups was similar, and the venlafaxine worked by 65.2% , while the clomipramine 72.2% （ P 〉 0.05 ）. 2. There was positive correlation between effect and course of disease. Short course of disease, good effect. 3. Gender difference ： male had better effect than female. 4. Side - effect （TESS） ： venlafaxine was lighter than clomipramine,and was temporary,endurable. 5. Venlafaxine worked fast and was good at loosing obsessive thoughts, while clomipramine was good at loosing obsessive behavior. Conclusion Venlafaxine is effective to OCD, especially on obsessive behavior. It works fast with light side - effect and male or short course of disease will have better effect.