P53蛋白表达在上皮性卵巢癌中的临床意义

P53 protein expression in epithelial ovarian carcinoma

目的探讨抑癌基因P53蛋白在上皮性卵巢癌中的表达及与预后的关系,建立有效的判断疾病进展及预后的指标。方法应用免疫组织化学方法检测72例上皮性卵巢癌患者P53蛋白的表达,研究其与临床分期、病理类型、组织分化及预后的相关性研究。结果上皮性卵巢癌中P53蛋白有一定的表达缺失,在G1、G2级组织表达率显著低于G3;不同的临床分期中,Ⅰ、Ⅱ期阳性表达显著低于Ⅲ、Ⅳ期;在浆液性和粘液性两种类型无明显差异。P53(-)和P53(+)患者化疗的5年生存率分别为60.71%和27.27%,差异有统计学意义(P<0.05)。结论P53蛋白表达与肿瘤细胞的分期分化程度有关,与肿瘤组织学类型无关。P53蛋白表达可作为卵巢癌预后和化疗耐药的一个指标。

Objective To investigate the prognostic value of P53 expression for the epithelial ovarian carcinoma and to establish an effective index to predict the progression and prognosis. Methods P53 protein expression was examined by immunohistochemical method in 72 patients with epithelial ovarian carcinoma and clinical staging, histologic types, tissue differentiation was analyzed. Results The P53 protein was less expressed in G1 and G2 groups than in G3 group. Moreover,P53 protein expression varied among different clinical stages. P53 expression in stages Ⅰ and Ⅱwere less than that of stages Ⅲ and Ⅳ. There was no significant difference between P53 expression and histological types. The P53 expression was associated with the 5 - year survival - free rate in patients with P53 negative and P53 positive were 60.71% and 27.27%, respectively, the difference was significant （P 〈 0.05）. Conclusion P53 protein expression related with the histological grade and clinical stages, but not with the histological type. P53 expression could he as a factor both in predicting prognosis of patients and anti - cancer drug resistance in epithelia ovarian cancer.