血小板激活因子及其受体拮抗剂对创伤性脊髓水肿的影响

EFFECT OF PLATELET ACTIVATING FACTOR AND ITS RECEPTOR ANTAGONIST ONTRAUMATIC SPINAL CORD EDEMA

采用猫鞘内注射血小板激活因子（ＰＡＦ）及静脉注射ＰＡＦ受体拮抗剂ＢＮ５２０２１观察其对猫脊髓损伤后脊髓水肿的影响。结果显示，ＰＡＦ能够增加损伤后脊髓组织含水量及Ｎａ＋、Ｃａ２＋含量；降低Ｋ＋、Ｍｇ２＋含量；ＢＮ５２０２１而能够降低伤后脊髓组织含水量，维持脊髓组织Ｎａ＋、Ｋ＋、Ｃａ２＋、Ｍｇ２＋含量的相对稳定，提示ＰＡＦ及其受体在创伤性脊髓水肿的病理生理过程中起重要作用，而ＰＡＦ受体拮抗剂能有效地减轻创伤性水肿。

The effect of platelet activating factor(PAF )and its antagonist BN5202l on spinal cord edema fol-lowing spinal cord injury of cats was observed after they were injected intrathecally and intrarvenously on spinalcord edema following spinal cold injury. Results showed that PAF could increase water content,Na+,Ca2+ levelsand decrease K+,Mg2+ levels in spinal cord tissue after tuauma; BN52021 could evidently decrease water contentand sustain the relative stability of Na+,K+,Ca2+,Mg2+levels.It suggested that PAF and PAF receptor playedan important role in the pathophysiological process of traumatic spinal cord edema,PAF antagonist could effec-tively improve traumatic spinal cord edema.