银屑病患者细胞CD11b、CD18及IL-8、IFN-γ变化的相关性研究

Clinical Significance of CD11b,CD18,IL-8 and IFN-γ in Patients with Psoriasis

目的探讨CD11b、CD18、白细胞介素8(IL-8)及γ干扰素(IFN-γ)等细胞因子在银屑病发病机制中的作用。方法选择寻常型、脓庖型、关节病型和红皮病型银屑病患者55例为病例组,同时选择40例健康正常者做对照组。应用流式细胞术对CD11b、CD18进行检测;用全自动酶标仪对IL-8、IFN-γ进行检测。结果银屑病患者的CD11b、CD18、IL-8及IFN-γ表达上调(P<0.01),与正常对照组比较,差别有统计学意义(P<0.01)。结论CD11b、CD18、IL-8及IFN-γ的过度表达,可能提示在银屑病患者免疫病理机制中的T淋巴细胞活化模式,对银屑病患者的免疫机制和指导治疗有指导意义。

Objective To explore, the clinical significance of cytokines expression including CD11b, CD18, IL-8 and IFN-γin patients with psoriasis. Methods 55 patients with psoriases, including vulgaris, pustulosa, arthropathica and erthrodermic ones, were enrolled into the case group and 40 healthy persons as control. The expressions of CD11b, CD18 were detected by flow cytometry, while IL-8 and IFN-γ with ELISA. Results The expression of CDllb, CD18, IL-8 and IFN-γin patients with psoriasis was significantly higher than those in control. Conclusions The ultra expression of CD1 lb, CD18, IL-8 and IFN-γ might relate with the immunopathology of lymphocyte cell activation in psoriasis. This might provide the dependable basis for its treatment.