老年病房2000～2004年铜绿假单胞菌耐药性变迁分析

Analysis on antimicrobial resistance of Pseudomonas aeruginosa during 2000～2004 in the wards for the elderly

目的监测老年患者医院感染铜绿假单胞菌对13种临床常用抗菌药物耐药性的变化趋势。方法利用全自动微生物鉴定系统VITEK-60对老年病房患者(年龄≥60岁)在2000年1月至2004年12月期间分离的1101株铜绿假单胞菌进行鉴定和体外抗菌药物活性测定。结果铜绿假单胞菌主要从呼吸道标本分离得到,在5202株病原菌中共分离得到1101株铜绿假单胞菌,分离率为21．2%,位居所有病原菌之首。同时,铜绿假单胞菌对13种抗菌药物的敏感性随时间下降。13种常用抗菌药物中,只有妥布霉素、哌拉西林/三唑巴坦、亚胺培南的敏感率大于50%,其中,妥布霉素的敏感性在五年间下降最少,仍保持在80%以上。结论铜绿假单胞菌是老年患者感染的重要病原菌,且耐药程度高,应引起实验室和临床医师高度重视。

Objective To survey the change of antimicrobial resistance of Pseudomonas aeruginosa during 2000- 2004 in the wards for the elderly. Method Antimicrobial susceptibilities of 1101 Pseudomonas aeruginosa were tested by VITEK-60. Result Pseudomonas aeruginosa was the most predominant pathogen. The activity of these 13 antibiotics against Pseudomonas aeruginosa decreased. The susceptibility rates of Pseudomonas aeruginosa to tobramycin piperacillin/tazobactam and imipenem were over 50%. And Tobramycin was the only antibitics whose susceptibility rate unchanged in 5 years. Conclusion Pseudomonas aeruglnosa was an important pathogen in the wards for the elderly. Clinicians should paid more attention on it.