儿童肺炎支原体肺炎血清中降钙素原的含量及其临床意义

Serum PCT level in children with MPP and the clinical value

目的探讨肺炎支原体肺炎（MPP）患儿的血清降钙素原（PCT）测定值及临床意义。方法观察组为2005年8月～10月诊断为MPP的住院患儿56例，其中急性期33例，恢复期23例。入院24h内取外周静脉血，同时抽取13名正常体检儿童（正常对照组）外周静脉血，采用发光免疫分析法定量测定PCT。结果观察组患儿急性期和恢复期血浆PCT平均值分别为（0．2706±0．1353）ng／ml和（0．1770±0．0582）ng／ml，正常对照组儿童PCT平均值为（0．1462±0．0310）ng／ml。急性期PCT与恢复期比较差异有显著性（P〈0．001），恢复期PCT与正常对照差异无显著性（P〉0．05）。结论MPP在急性期PCT仅轻度增高，在恢复期降至正常范围。

Objective To investigate the serum PCT level and the clinical value in children with MPP. Methods Fifty-eight inpatient children with MPP were recruited from 2005.8 to 2005.10, which ineluded 35 patients in acute phase and 23 patients during rehabilitation. The venous blood samples of the 58 patients were obtained in 24 hours after their admission to the hospital. Thirteen healthy children were recruited in this study as a control group, whose venous blood samples were gained during the same period. Serum levels of PCT were measured by immunoluminometric assay. Results The PCT level of patients in acute phase was （0. 270 6 ± 0-135 3）ng/ml; while it was （0.1770 ± 0. 058 2）ng/ml in patients during rehabilitation and （0. 146 2 ± 0.031 0）ng/ml in the control group. The serum PCT of patients in acute phase was higher than the patients during rehabilitation（P 〈 0.05）. There was no significant difference between the control group and the patients during rehabilitation. Conclusion The serum PCT level presents light increase in patients with MPP who are in the acute phase. The PCT level drops to normal level during rehabilitation.