晚发性维生素K缺乏致颅内出血危险因素分析

Analysis of risk factors in intracranial hemorrhage of late vitamin K deficiency

目的探讨晚发性维生素K缺乏致颅内出血发病的危险因素。方法对57例晚发性维生素K缺乏致颅内出血进行了总结,并应用非条件Logistic回归分析,对8项可能的危险因素进行分析。结果晚发性维生素K缺乏致颅内出血发病危险模型Y=-4.405+1.652X1+2.418X2+2.076X3+2.782X7+1.617X8,X1=性别,X2=年龄,X3=喂养方式,X7=CMV感染,X8=肝功能异常。结论男性、年龄<3个月、纯母乳喂养、有CMV感染、肝功能异常者易发生晚发性维生素K缺乏致颅内出血。

Objective To investigate the risk factors of onset of intracranial hemorrhage induced by late vitamin K deficiency . Methods Fifty-seven children with intracranial hemorrhage induced by late vitamin K deficiency were retrospectivly reviewed and eight pcssible risk factors were analyzed by Logistic regression method. Results The onset hazard model of intracranial hemorrhage of late vitamin K deficiency was valued as：Y= - 4.405 ＋ 1.652X1 ＋2.418X2 ＋ 2.076X3 ＋ 2.782X7 ＋ 1.617X8, among them X1 was defined as sex, X2 was defined as age, X3 was defined as feeding mode, X7 was defined as infection of cytomegalovirus, X8 was defined as abnormal hepatic function. Conclusion Children of male, with age less than 3 year, only feeded with woman milk, with infection of cytomegalovirus, with abnormal hepatic function were easily to take place intmcranial hemorrhage of late vitamin K deftciency.