期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白念珠菌菌丝发育的遗传调控 被引量：2

Genetic Regulation of Hyphal Development in Candida albicans
下载PDF
导出
摘要 白念珠菌(Candidaalbicans)是人体内最重要的机会型致病真菌,能以酵母、假菌丝、菌丝等多种形态存在。白念珠菌的菌丝发育与它的致病性成正相关,这一过程由胞内多种信号转导途径所调控。现对控制白念珠菌菌丝发育的主要信号转导途径进行综述。 The important opportunistic fungal pathogen Candida albicans exists in yeast, pseudohyphal and hyphal forms. Morphological transition from yeast to hyphae in C. albicans is regulated by a variety of cellular signal transduction pathways under different environmental conditions. This review focuses on recent research progress on major signal transduction pathways regulating the yeast to hyphae transition process in C. albicans.
作者 蒋伶活 李西川 智慧
机构地区 天津大学药物科学与技术学院
出处 《细胞生物学杂志》 CSCD 2006年第3期387-391,共5页 Chinese Journal of Cell Biology
基金 国家自然科学基金资助项目(No.30470850)~~
关键词 白念珠菌 菌丝发育 遗传调控 MAPK级联 CAMP-PKA Candida albicans hyphal development genetic regulation MAPK cAMP-PKA
分类号 R379.4 [医药卫生—病原生物学]
  • 相关文献

参考文献36

  • 1Braun BR et al. PLoS Genet, 2005, 1:36
  • 2Whiteway M. Curr Opin Microbiol, 2004, 7:350
  • 3Berman Jet al. Nat Rev Genet, 2002, 3:918
  • 4Liu H. Curr Opin Microbiol, 2001, 4:728
  • 5Liu H et al. Science, 1994, 266:1723
  • 6Chen J et al. Mol Microbiol, 2002, 46:1335
  • 7Ikner A et al. Mutat Res, 2005, 569:13
  • 8Smith DA et al. Mol Biol Cell, 2004, 15:4179
  • 9Kumamoto CA. Proc Natl Acad Sci USA, 2005, 102:5576
  • 10Leng P et al. J Bacteriol, 2001, 183:4090

同被引文献15

  • 1Whiteway M, Bachewich C. Morphogenesis in Candida albi-c?/i,s[J]. Annu Rev Microbiol, 2007,61: 529-553.
  • 2Fonzi W A, Irwin M Y. Isogenic strain construction andgene mapping in Candida (dbicans[S]. Genetics, 1993, 134(3):717-728.
  • 3Zheng C,Yan Z, Jiang L, et aL Identification and charac-terization of a functional Candida aibicons homolog of the Sac-charomyces cerevisiae TC089 gene [J]. FEMS Yeast Res,2007, 7(4): 558-568.
  • 4Wilson R B, Davis D, Mitchell A P. Rapid hypothesistesting with Candida (ill)icons through gene disruption withshort homology regions [J]. J Bacteriol, 1999, 181 (6): 1868-1874.
  • 5Lee C M, Nantel A, Jiang L, et al. The serine/threonineprotein phosphatase S1T4 modulates yeast-to-hypha morpho-genesis and virulence in Candida albicans [JJ. Mol Microbiol,2004, 51(3): 691-709.
  • 6Wang J, Yan Z, Jiang L, et al. Expression of CaPTC7 isdevelopmentally regulated during serum -induced moiphogene-sis in the human fungal pathogen Candida albicans |J |. Can JMicrobiol, 2007, 53(2): 237-244.
  • 7Ward A C. Rapid analysis of yeast transfonnants usingcolony-PCR[J]. Hiotechniques, 1992, 13(3): 350.
  • 8David C, Amberg, Daniel J. Methods in yeast genetics[M].New York: Cold Spring Harbor Laboratory Press, 2005.
  • 9Jiang L. White wav M, Shen S H. A novel type 2C proteinphosphatase from the human fungal pathogen, Candida albicans[J]. FEBS Lett, 2001,509(1): 142-144.
  • 10Jiang L, Lee C M,Shen S H. Functional characterizationof the C. albicans homologue of secretion associated and Rm-related (Sari) gene[J]. Yeast, 2002, 19(5): 423-428.

引证文献2

二级引证文献1

细胞生物学杂志
2006年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部