内源性气体硫化氢在中枢神经系统中的作用

Functions of Endogenous Gaseous Hydrogen Sulfide in Central Nervous System

内源性硫化氢(H2S)可以刺激神经细胞cAMP水平增加,提高NMDA受体介导的突触后兴奋性电位,提高诱导海马长时程增强。H2S不仅具有神经调节剂的功能,还有神经保护剂的功能。H2S自身并不能将细胞从氧化应激中解救出来,但是它能通过提高胞内有效的抗氧化剂——还原型谷胱苷肽的含量而起到保护神经元的作用。对H2S的研究刚刚起步,对其在神经系统中的作用机制开展研究将有助于了解其在神经元保护方面所起的作用。

Endogenous hydrogen sulfide （H2S） call increase the production of cAMP, potentiate the exciting postsynaptic potential mediated by NMDA receptor and enhance the induction of hippocampal long-term potentiation. In central nervouse system, H2S functions as a neuromodulator as well as a neuroprotectant. H2S itself does not rescue cells from oxidative stress; instead it protects neurons by increasing the level of a major and potent antioxidant, reduced glutathione. The study of H2S is very new. Understanding the mechanism of its physiological function may provide a new insight into its neurons protection.