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FoxO转录因子在代谢调节及肿瘤抑制中的作用 被引量：7

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作者 甘立霞
机构地区 第三军医大学基础医学部生物化学与分子生物学教研室
出处 《第三军医大学学报》 CAS CSCD 北大核心 2006年第12期1347-1350,共4页 Journal of Third Military Medical University
基金 国家自然科学基金资助项目(30570888)~~
关键词 FOXO 转录因子 代谢 肿瘤
分类号 R394.3 [医药卫生—医学遗传学]
  • 相关文献

参考文献31

  • 1KAESTNER K H,KNOCHEL W,MARTINEZ D E.Unified nomenclature for the winged helix/forkhead transcription factors[J].Genes Dev,2000,14 (2):142-146.
  • 2CLARK K L,HALAY E D,LAI E,et al.Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5[J].Nature,1993,364 (6436):412-420.
  • 3ACCILI D,ARDEN K C.FoxOs at the crossroads of cellular metabolism,differentiation,and transformation[J].Cell,2004,117(4):421-426.
  • 4ANDERSON M J,VIARS C S,CZEKAY S,et al.Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily[J].Genomics,1998,47 (2):187-199.
  • 5FURUYAMA T,NAKAZAWA T,NAKANO I,et al.Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues[J].Biochem J,2000,349 (Pt 2):629-634.
  • 6JACOBS F M,Van-DER-HEIDE L P,WIJCHERS P J,et al.FoxO6,a novel member of the FoxO class of transcription factors with distinct shuttling dynamics[J].J Biol Chem,2003,278 (38):35959-35967.
  • 7BARTHEL A,SCHMOLL D,UNTERMAN T G.FoxO proteins in insulin action and metabolism[J].Trends Endocrinol Metab,2005,16(4):183-189.
  • 8ZHAO X,GAN L,PAN H,et al.Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1:characterization of phosphorylation-and 14-3-3-dependent and -independent mechanisms[J].Biochem J,2004,378(Pt 3):839-849.
  • 9RENA G,WOODS Y L,PRESCOTT A R,et al.Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion[J].EMBO J,2002,21(9):2263-2271.
  • 10ZHANG X,GAN L,PAN H,et al.Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms.Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding[J].J Biol Chem,2002,277(47):45276-45284.

同被引文献99

  • 1汤正好,马会慧,臧国庆,余永胜,李刚,姚集鲁.抗HBc-ScFv基因复制缺陷型腺病毒载体的构建及其体外表达[J].世界华人消化杂志,2005,13(6):734-738. 被引量：2
  • 2管海涛,薛兴欢,王西京,李昂,秦兆寅.靶向survivin的siRNA抑制乳腺癌MCF-7细胞增殖并诱导其凋亡[J].中华肿瘤杂志,2006,28(5):326-330. 被引量：22
  • 3Accili D. Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic [J]. Diabetes, 2004,53(7): 1633-1642
  • 4Zhang W, Feng D, Li Y, et al. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis [ J ]. Cell Metab, 2006, 4 (6) : 491-497
  • 5Matveyenko A V, Butler P C. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes [ J ]. Diabetes, 2006, 55(7):2106-2114
  • 6Butler A E, Janson J, Bonner-Weir S, et al. β-cell deficit and increased β-cell apoptosis in humans with type 2 dabetes [ J ]. Diabetes,2003,52( 1 ) : 102-110
  • 7Sakuraba H, Mizukami H, Yagihashi N, et al. Reduced β-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type 2 diabetes patients [ J ]. Diabetologia, 2002,45 ( 1 ) : 85- 96
  • 8Robertson R P, Harmon J, Tran P O, et al. β Cell glucose toxicity, lipotoxicity and chronic oxidative stress in type 2 diabets [ J ]. Diabetes, 2004,53 ( Suppl 1 ) : s119-124
  • 9Valenti L, Rametta R, Dongiovanni P, et al. Increased expression and activity of the transcription factor FOXOI in nonalcoholic steatohepatitis[J]. Diabetes, 2008, 57(5) : 1355-1362
  • 10Liu P, Kao T P, Huang H. CDKI promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor[J]. Oncogene, 2008,27(34):4733-4744

引证文献7

二级引证文献32

第三军医大学学报
2006年 第12期

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