创缘周围血管生成在皮肤损伤时间推断中的应用

Application of micro-vascularity incurred during skin wound repair to wound age determination

皮肤损伤时间推断一直以来都是法医病理学者所需解决的重要问题,免疫组织化学技术具有方便、敏感的特性,它的应用大大提高了皮肤损伤时间推断研究的发展。然而,有效指标的缺乏却限制了免疫组织化学技术的应用。血管生成在皮肤损伤愈合过程中发挥着非常重要的作用,因此,血管生成相关因子可能在皮肤损伤时间推断方面具有重要价值。

Determination of wound age has long been one of the most important missions of the forensic pathologist in practice. During the last several decades, the use of immunohistochemical technique, which is considered as a convenient and sensitive method, has greatly improved the potential to estimate wound age. However, the lack of effective immunohistochemical markers has greatly limited the application of the technique. Angiogenesis plays a critical role during wound healing process. Therefore, some biological factors involved in angiogenesis may be possibly useful markers for wound age determination.