乙型肝炎病毒感染与DNA甲基化

Hepatitis B virus infection and DNA methylation

乙型肝炎病毒(HBV)感染是导致肝癌的重要病因,但HBV感染与肝癌中DNA甲基化改变的研究较少。此文综述HBV感染导致全基因组低甲基化和抑癌基因启动子高甲基化的研究现况,为进一步深入探讨 HBV相关性肝癌的发病机制提供新的思路。

HBV is an important risk factor of hepatoma. There is a few studies on the relation of HBV infection and DNA methylation. Here reviews current opinions about hypomethylation of total genomic DNA and hypermethylation of tumor suppressor gene induced by HBV infection. It will provide a novel idea on the pathogenesis of HBV related hepatoma.