摘要
胃癌的发生发展是一个涉及多基因多步骤的复杂过程。随着研究的不断深入,人们开始关注DNA 甲基化这种表遗传学修饰方式在胃癌发生过程中的作用。DNA的异常甲基化通过影响基因转录,促基因突变,增加染色体结构的不稳定性等多方面促进胃癌的发生发展。随着DNA甲基化研究的不断深入,甲基化的检测技术也不断革新。基因启动子甲基化已经作为一种重要的肿瘤生物学标志被应用于胃癌的临床诊断,甲基化制剂作为抗肿瘤药物也逐步应用于临床。
Gastric tumorigenesis is a complicated process involved a lot of steps and aberrant genes. Until now , DNA methylation as an epigcretic modification way has conducted as a focus in gastric carcinoma research. Aberrant DNA methylation reinforce the gastrical tumorigenesis by promoting gene mutation and enhancing the chromatosome instability , etc. With the development of DNA methylation research, the technology detecting the situation of DNA methylation also made some progress and it had widely used in gastric cancer research. In addition, gene promoter methylation has been acted as an important tumor marker in diagnosis of stomach cancer and the agent for regulation DNA methylation have also been used in treatment of gastric carcinoma.
出处
《国际消化病杂志》
CAS
2006年第3期201-203,共3页
International Journal of Digestive Diseases
关键词
甲基化
胃癌
抑癌基因
DNA methylation
Gastric carcinoma
Tumor suppression gene
