生长抑素及其类似物与胰腺癌关系的研究现状

Relationship between Somatostatin with its Analogs and Pancreatic Cancer

胰腺癌是常见的胰腺肿瘤,其早期诊断困难,对放、化疗均不敏感,至今尚无理想的治疗方法。近年来研究发现生长抑素具有抗细胞增殖的作用,并发现胰腺中有许多生长抑素受体亚型的表达,已引起临床关注。目前对生长抑素受体和生长抑素对肿瘤作用的实验研究较多,临床应用相对较少,而且疗效也不甚理想。其原因目前认为有:人体的某些肿瘤对该疗法不敏感;人体肿瘤缺乏生长抑素受体;治疗前多数患者已行化疗或处于广泛转移状态影响疗效。但近来应用生长抑素联合其他疗法取得了一定效果。生长抑素及其类似物对肿瘤的抑制作用及与其受体的高度亲和性,为基因治疗胰腺癌提供了可能,以生长抑素为载体的导向治疗为肿瘤的治疗提供了一条新途径。

Pancreatic Cancer is a common pancreatic neoplasm, whose early diagnosis is difficult and not sensitive to chemotherapy and radiotherapy. Up to now, there is no ideal treatment method. In the recent years, it is discovered that somatostatin has the ability to anti - cell - proliferation and there are many somatostatin receptor second types expression in the pancreas. This point is causing people＇s concern. New experiments to study the functions of somatostatin and its receptors to tumors are popular, but the clinical applications are less and the curative effects are not very ideal. There are the considered causes, for example, some body tumors are not sensitive to this treatment, body tumors are lack of somatostatin; most patients had chemotherapy or were in the transferring state before the treatment, which effects the curative effect. But some progress has been made by applying somatostatin combined with some other methods. Somatostatin and its analogs have the functions to suppress tumors and the high affinity to its receptors, which provide a probability of gene therapy to pancreatic cancer and a new way for treating tumors guided by somatostain.