摘要
为了解受创组织修复过程中氧化与抗氧化能力的变化,以酶学法测定了大鼠刀伤创面肉芽组织匀浆中超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-PX)的含量。伤后3、5、7d的SOD、GSH-PX含量呈"V"型改变,GSH呈"∧"型改变,MDA逐渐升高,伤后7d与3d的SOD及MDA比较,均呈显著性差异(P<0.05)。结果提示,创伤修复中局部组织存在脂质过氧化反应;组织中抗氧化酶含量的分布与修复质量有关;如果在愈合不同阶段应用外源性抗氧化剂,可能有利于创伤修复。
The changes of superoxide dismutase (SOD), malonyldialdehyde (MDA), glutathione (GSH), and glutathione peroxidase (GSH-PX) contents in granulation tissues were observed in resected wounds of rats. The results revealed that the curve of SOD and GSH-PX changes was showed in '∨' type, while in GSH was showed in '∧' type,and MDA content increased gradually after resection. The contents of SOD and MDA were higher at day 7 than day 3(P<0.05). It was concluded that the changes of SOD,MDA,GSH and GSH-PX contents were present in the process of wound healing.
出处
《上海实验动物科学》
1996年第1期8-10,共3页
Shanghai Laboratory Animal Science
