摘要
同源异形域蛋白是真核生物中一类重要的转录因子．根据同源盒基因及其同源异形域产物的肽链结构可以分为多种家族．文章综述了同源异形域与ＤＮＡ结合的一般特点．并叙述了Ａｎｔｐ、ＰＯＵ等重要类型的转录因子如何识别ＤＮＡ位点、ＨＴＨ及其他蛋白质在识别中如何起作用．
Homeodomain proteins are very important regulation factors in eukaryotic transcription and development. They are classified into many families according to structure of homeobox genes and homeodomain peptide chains. The interaction of homeodomain and DNA was characterized. How the Antp andPOU homeodomains recognized the binding sites of DNA sequences was explained. The function of HTH structure and other proteins in recognition were also described.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1996年第1期29-33,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金
关键词
同源异形域结构
DNA
位点
识别
homeodomain structure, protein-DNA interaction, transcription factor, HTHstructure
