氧化与细胞凋亡

Oxidative Stress induced Apoptosis

细胞凋亡（ａｐｏｐｔｏｓｉｓ）是细胞的主动死亡，它参与调节机体许多生理及病理过程．近年的研究表明细胞凋亡与氧化有密切关系．当细胞外诸如辐射、高氧、高温、感染、衰老等信息通过活性氧传入细胞，引起细胞脂质过氧化或与细胞凋亡有关的基因的表达，通过一系列生化反应，最终发生细胞凋亡．原癌基因ｂｃｌ－２可能起着调节作用．

Apoptosis, an active process of cellular self-destruction involved in a variety of physiological and pathological conditions, can be induced by either oxidants or stimulators of cellular oxidative stress. Mild damages such as ionizing and ultraviolet radiation, hyperoxia,hyperthermia, infection etc, will injure the cell via reactive oxygen species (ROS), which may either react with the polyunsaturated fatty acids,leading to the formation of oxidized lipids, or activate certain genes related to cell death. As a result, the cell commits suicide following a sequence of biochemical change. hcl-2, one of the proto-oncogenes, was found to play a role in the regulation of apoptosis.