超氧化物歧化酶模拟化合物的生物活性研究

Study on Biological Activities of Mimic Superoxide Dismutase

根据天然超氧化物歧化酶（ＳＯＤ）活性部位结构合成了含苯并咪唑的５种配体及其３２种分别含Ｃｕ（Ⅱ）、Ｆｅ（Ⅲ）、Ｍｎ（Ⅱ）、Ｃｏ（Ⅱ）的模拟化合物经光谱、电化学测试证明这些化合物具有拟Ｓ３Ｄ活性，其５０％抑制率浓度（ＩＣ５０）为１０－６～１０－８ｍｏｌ·Ｌ－１。

Five ligands containing benzimidazolyl and 32 compounds of their containing copper (Ⅱ), iron(Ⅲ), manganese (Ⅱ), cobalt (Ⅱ) have been synthesized based on the active site structures of natural superoxide dismutase (SOD), respectively. It has been shown that these compounds possess mimetic SOD activities by spectroscopic and electrochemical measurements. The concentrations of 50% inhibition (IC50) are within 10-6～108 mol·L-l. The rate constants (kq ) of catalytic dismutation of superoxide radicals (O2) are in the range of 106～108 mol-1·L·s-1. Simultaneously it has been observed that a several mimetic compounds of then have antineoplastic activities and increasing antifreezing effect of rices.