摘要
根据天然超氧化物歧化酶(SOD)活性部位结构合成了含苯并咪唑的5种配体及其32种分别含Cu(Ⅱ)、Fe(Ⅲ)、Mn(Ⅱ)、Co(Ⅱ)的模拟化合物经光谱、电化学测试证明这些化合物具有拟S3D活性,其50%抑制率浓度(IC50)为10-6~10-8mol·L-1。
Five ligands containing benzimidazolyl and 32 compounds of their containing copper (Ⅱ), iron(Ⅲ), manganese (Ⅱ), cobalt (Ⅱ) have been synthesized based on the active site structures of natural superoxide dismutase (SOD), respectively. It has been shown that these compounds possess mimetic SOD activities by spectroscopic and electrochemical measurements. The concentrations of 50% inhibition (IC50) are within 10-6~108 mol·L-l. The rate constants (kq ) of catalytic dismutation of superoxide radicals (O2) are in the range of 106~108 mol-1·L·s-1. Simultaneously it has been observed that a several mimetic compounds of then have antineoplastic activities and increasing antifreezing effect of rices.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1996年第2期159-163,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金
湖北省自然科学基金
南京大学配位化学国家重点实验室基金
关键词
超氧化物歧化酶
模拟化合物
生物活性
superoxide dismutase,mimetic compound, biological activity