摘要
目的了解慢性阻塞性肺病(COPD)患者炎症发生过程中血清瘦素、肿瘤坏死因子水平的变化与营养不良及低氧血症的关系。方法选择住院COPD患者30例,按病程分为急性加重期和临床稳定期,在不同时期测定瘦素(leptin)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)、血清白蛋白(ALB)及动脉血气分析指标,计算体重指数(BMI)、理想体重百分比(NW%)、呼吸频率(R),选择同期正常对照组15例相比较。结果急性加重期leptin、TNF-α、CRP、ALB、动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、动脉血氧饱和度(SaO2)、R与临床稳定期及对照组相比差异有统计学意义(P<0.01),急性加重期leptin与TNF-α、CRP、R、PaCO2、BMI、NW%呈正相关,与PaO2、SaO2呈负相关,TNF-α与PaCO2呈正相关,与PaO2呈负相关。结论COPD患者急性加重期低氧血症状态下lep-tin、TNF-α、CRP水平明显增高,可将其作为急性加重期的炎性标志物。炎性状态下,瘦素和细胞因子联合作用,加重患者营养不良。
Objective To investigate the change of serum leptin, tumor necrosis factor-α in various period in the patient with chronic obstructive pulmonary disease （COPD） and the association between leptin, TNF-α and malnutrition as well as condition of low oxygen. Methods 30 patients with COPD from hospitalization were classified as acute exacerbation and stationary phase according to progressing. The leptin,tumor necrosis factor-α（TNF-α） , C-reactive protein （CRP） , Serum albumin （ALB） were tested and the arterial gas analysis counting, Body mass index （BMI） ,Percent age of normal body weight （ NW%）, Breathe the frequency （R） were measured. Results The Leptin, TNF-α, CRP, ALB,PaO2 （The oxygen cent presses） ,PaCO2 （The carbon dioxide cent presses） ,SaO2 （Saturated degree of oxygen） and R were significantly different between the acute exacerbation phase and stationary phase, the control group in the patients （P〈0. 001）. The levels of leptin was positively correlated with TNF-α,CRP,R,PaCO2 ,BMI, NW% in acute exacerbation phase. It was negatively correlated with PaO2 ,SaO2. The levels of TNF-α was positively correlated with PaCO2 and it was negatively correlated with PaO2. Conclusion The leptin,TNF-α,CRP are inflaming marks of the acute exacerbation phase in the patients with COPD. Under the imflammation appearance, the effects of leptin and cell factors could increase malnutrition.
出处
《贵州医药》
CAS
2006年第6期506-508,共3页
Guizhou Medical Journal
