槐耳颗粒对乳腺癌患者术后免疫功能调节作用的观察

Effect of huaier granules on immune function in patients with breast cancer after modified radical mastectomy

目的：观察槐耳颗粒（金克）对乳腺癌患者术后免疫功能的调节作用.方法：50例乳腺癌改良根治术患者,随机分为金克组和对照组,金克组在术后第2～5天开始服用金克20 g,3/d,30 d为1疗程,对照组服用安慰剂,其余治疗同金克组.两组于术后第2天晨及1个疗程结束后第1～4天测定血中IgA、IgG、IgM、淋巴细胞计数、T淋巴细胞亚群分类.结果：金克组淋巴细胞计数和IgA,IgC,IgM,均比对照组提高显著.金克组和对照组的CD3、CD4、CD8、CD4/CD8研究后与研究前比较,金克组CD3研究后高于研究前（P＜0.05）,而对照组无明显区别;口服金克30 d后,金克组的CD3、CD4/CD8高于对照组.结论：槐耳颗粒有助于乳腺癌患者术后体液免疫功能和细胞免疫功能的恢复.

Objective：To elucidate the effect of huaier granules on immune function in patients with breast cancer after modified radical mastectomy. Methods：Fifty patients with breast cancer after modified radical mastectomy were randomly divided into two groups： JINKE group,control group. JINKE group patients had been given huaier granules at 20 g,tid for 30 days from the pastoprative day 2-5, control group had been given same weight placebo. IgA, IgG, IgM, total lymphocyte count, peripheral blood T lymphocyte subset were measured. Results：After 30 days of oral JINKE intake, IgA, IgG, IgM, total lymphocyte count in JINKE group were significantly higher than that in control group. On the other hand, CD3 of JINKE group was increased significantly（P〈0. 05） compared with the day before test and it remained almost the same in control group. In addition, CD3, CD4/CD8 in JINKE group was significantly higher than that in control group too. Conclusion：Huaier granules helps to ameliorate the immune function in patients with breast cancer after modified radical mastectomy.