尿激酶型纤溶酶原激活物在人脑胶质瘤的表达与随访分析

Expressing of urokinase-type plasminogen activator in human glioma and correlated follow-up study

目的:研究尿激酶型纤溶酶原激活物在人胶质瘤中的的表达,及其在中枢神经系统肿瘤的预后判断中的作用。方法:采用免疫组化方法检测102例人胶质瘤标本的uPA表达情况,追踪患者预后,并通过多因素分析评估其预后作用。结果:uPA在恶性胶质瘤呈高水平表达,而低级别胶质瘤中表达较弱甚至不表达。uPA水平与胶质瘤影像水肿表现显著相关。结论:uPA的高水平表达与胶质瘤的恶性程度显著相关,并可作为星形细胞瘤的一种独立预后指标。

Objective：To evaluate the expression of urokinase-type plasminogen activator （uPA） in human glioma, and to estimate its prognostic role. Methods：The expressing of uPA in 102 human astrocytoma were detected by immunohistochemistry, and was compared with the pathological characteristics as well as the follow-up data in these patients. Results：High levels of uPA were seen in malignant glioma, whereas low levels of uPA or no expression were found in low-grade gliomas. There is a significant correlation between the uPA level and the peritumoral edema which was revealed by the radiographic analysis. Patients with high uPA level had a statistically significant poor prognosis than those with low uPA level. Conclusions：The level of uPA was correlated with the malignant phenotype of human glioma and can be a independent prognostic indicator.