老年人血清胆红素与冠心病相关分析

Relationship between the level of serum bilirubin and the severity of coronary lesion in the elderly

目的探讨老年人血清胆红素与冠状动脉病变的关系。方法对符合条件的经冠脉造影确诊的老年冠心病患者135例,测定血清总胆红素、直接胆红素、血脂水平及冠状动脉狭窄程度进行Gensini评分,并分为4组(A^D),A组(0分);B组(1~20分);C组(21~40分);D组(>40分)。结果冠心病组血清胆红素水平明显低于对照组(P<0·01),且随着冠状动脉狭窄程度的加重,血清胆红素水平逐渐下降。相关分析结果显示,血清总胆红素、直接胆红素与血浆总胆固醇、三酰甘油、低密度脂蛋白胆固醇均呈负相关,与高密度脂蛋白胆固醇呈正相关。Logistic回归分析表明血清总胆红素与冠心病呈独立负相关(OR=0·913,P<0·05)。结论血清胆红素是冠心病一项独立的危险因素。

Objective To explore the relationship between the severity of coronary artery lesion and the level of se -rum bilirubin in the elderly. Methods 135 elderly patients undergoing coronary angiography were divided into 4 groups according to Gensini score：A（0） ;B（1-20） ;C（21-40） ;D（〉40）. Results The levels of TBIL and IBIL in CHD Group were significantly lower than those in control group（ P〈0.01 ） . The total bilirubin concentration of groups B, C and D gradually decreased. There was significant negative correlation between the serum levels of TBIL, IBIL and the serum levels of TC, TG, LDL-C. There was positive correlation between the serum level of bilirubin and the serum level of HDL-C. Independent negative correlation existed between serum bilirubin and the coronary artery disease. Conclusions The serum bilirubin may be a risk factor of coronary artery disease.