摘要
采用均匀设计法,优化了选定的合成路线,得到了合成奥美拉唑的最佳工艺条件:摩尔比n(硫醚)∶n(间氯过氧苯甲酸)=1∶1;反应液pH值为7.5;氧化剂添加时间2.5 h;反应温度-5℃;保温时间3.0 h.在此工艺条件下,其目的产品奥美拉唑的试验平均摩尔收率为92.07%,比现行工艺可提高至少2个百分点.新化合物及产品的结构经1H-NMR、MS得以确证.
The chosen route has been optimized with Uniformity Design. The best technical qualification of synthesis of omeprazole has been taken out. As following: mixed proportion of material: n(Pynnetazole) : n(M - Chlorobenzoic acid peroxidease) = 1 : 1, pH (reactivity liquid) = 7.5,accession time of oxidizer: 2.5 hours, temperature of oxidation: -5℃, time of heat preservation: 3.0 hours. On the technical qualification, the average yield of Omeprazole is92.07 %, has been elevated more than 2% primary synthesis technique. The structures of thenew compound and the product were identified by ^1H- NMR and MS.
出处
《哈尔滨商业大学学报(自然科学版)》
CAS
2006年第3期82-86,共5页
Journal of Harbin University of Commerce:Natural Sciences Edition
关键词
奥美拉唑
硫醚
药物合成
均匀设计
Omeprazole
pyrmetazole
pharmaceutical synthesis
uniformity design