77例冠心病PCI术前后C反应蛋白水平变化

Chandges of C-reactive protein level of 77 patients with coronary heart disease after percutaneous coronary intervention

目的探讨C反应蛋白(CRP)水平与冠心病的相关性以及行经皮冠状动脉介入治疗(PCI)术后的变化。方法采用酶联免疫吸附试验(ELISA)法测定经冠状动脉造影确诊的77例冠心病患者及78例冠状动脉造影正常者的血清CRP水平,并比较77例冠心病患者PCI术前后的血清CRP水平变化。结果冠心病患者血清CRP水平明显高于冠状动脉造影正常者,另外冠心病患者PCI术后血清CRP水平明显高于术前。结论CRP与冠心病发生密切相关;PCI能导致冠心病患者的内皮损伤,加重炎症反应,从而引起管腔再狭窄,因此PCI术后应加强抗炎治疗。

Objective To explore the relationship between C-reactive protein（CRP） level and coronary heart disease（CHD） and observe the change of CRP level after percutaneous coronary intervention（PCI）. Methods Peripheral blood samples were taken from 77patients of CHD diagnosed by coronary angiography（CAG） and 78 healthy subjects. The serum levels of CRP were measured by ELISA, and the change of serum levels of CRP in 77 patients of CHD treated with PCI were analyzed. Results The serum levels of CRP in the patients were higher than that in the healthy subjects,and the serum levels of CRP in the patients were higher after PCI. Conchtsion The serum levels of CRP are associated with CHD; PCI can damage the endotheliurn and exaggerate inflammatory response in patients of CHD and result in instent restenosis. Anti-inflammatory therapy should be enhanced after PCI.