血清CA125水平与肝硬化Child-pugh分级及腹水量的关系

The Relationship Between Serum CA125 Levels and Child-pugh Clas- sification of Liver Cirrhosis and Quantity of Ascites

目的探讨肝硬化患者血清肿瘤抗原125(CA125)水平与肝功能Child-pugh分级及腹水量的关系。方法肝硬化患者91例,Child-pughA级32例,B级36例,C级23例;腹水阳性者50例,腹水阴性者41例;正常对照32例。均采用ELISA法检测血清CA125水平。结果肝硬化患者血清CA125水平显著高于对照组(P<0.01),肝硬化患者血清CA125水平Child-pughC级>B级>A级,随着肝损害程度加重而进行性升高(P<0.01);肝硬化腹水组及少量腹水组血清CA125水平均显著高于肝硬化无腹水组(P<0.01),中量腹水组血清CA125水平显著高于少量腹水组(P<0.01),大量腹水组与中量腹水组的血清CA125水平比无统计学意义。结论肝硬化患者血清CA125水平与肝功能损害及腹水程度密切相关,可以被认为是反映肝硬化程度及监测腹水情况的一项敏感指标,对肝硬化腹水的早期诊断及估计预后具有较高的参考价值。

Objective To study the relationship between serum CA125 levels and Child-pugh classification of liver cirrhosis and quantity of ascites. Method A total of 91 patients were studied, consisting of 32 in Child-pugh A, 36 in B , 23 in G There were 50 patients with ascites and 41 without ascites; serum CA125 level were measured in all patients and in 32 normal persons by ELISA. Results The levels of serum CA125 in liver cirrhosis patients were significantly higher than in controls（P〈0.01） and in Child-pugh C 〉 in B 〉in A, increased gradually with aggravating lesion of the liver（P〈0.01）; Serum CA125 levels in liver cirrhosis with ascites group and with small amount ascites group were significantly higher than without ascites group （P〈0. 01）, with middle amount ascites group significantly higher than with small amount ascites group （P〈0. 01）, There were without statistics significance between comparison of serum CA125 levels in large amount ascites group and in middle amount ascites group. Conclusion The levels of serum CA125 in liver cirrhosis patients were osculating correlation with lesion of the liver and ascites degree, could serve as a sensitive marker for liver lesion degree and monitoring ascltes quantity, were of value to ear]y diagnosis and estimating prognosis for liver cirrhosis patients with ascites.