江苏省肾综合征出血热灭活疫苗免疫效果现场考核初报

Preliminary Field Observation on the Mass with Inactivated Vaccine against Haemorrhagic Fever with Renal Syndrome in Jiangsu PrOvince

对东海、赣榆、灌云东辛农场３个ＨＦＲＳ高发地区分别进行４８７１人份Ⅰ型疫苗、４５７１人份Ⅱ型疫苗和６６５８人份Ⅲ型疫苗的人群接种，并进行了１年期观察。结果：该两型苗的副反应均较低，安全性好，Ⅰ型疫苗全程免后２周荧光抗体阳转率为８４．４％，中和抗体阳转率为３７．０％；Ⅱ型疫苗荧光抗体阳转率为４８．８％，中和抗体阳转率为９４．５８％；Ⅰ型疫苗１年期内保护率为５６．０％，Ⅱ型疫苗为９３．０％。

In 1994, 4871 volunteers were inoculated with the whole course(three injections)of the inactivated Meriones ungiculetus kidney cell vaccine(type Ⅰ vaccine)in Donghai county; 4571 and 6658 volunteers were inoculated with the whole course(three injections )of inactivated hamster kidney cell vaccine(type Ⅱ vaccine)in Ganyu county and Dongxin farm, respectively. The three areas were serious endemic of HFRS. The observation during one year period showed: the two kinds of the vaccine were of slight side effect, safety for the volunteers. The seroconversion rate of fluorescent antithey and neutralizing antibody were 84. 4% and 37. 0%,two weeks after the whole course of immunization in the type Ⅰ group. In the typeⅡgroup,the seroconversion rate of fluorescent antibody and neutralizing antibody were 48. 8% and 94. 6%, respectively, The protective rates of the type Ⅰ and type Ⅱ vaccine were 56.0%and 93.0%by one year,respectively.