摘要
二乙基亚硝胺(DEN)诱发大鼠肝癌过程中,可使肝中增殖指标γ-谷氨酰转肽酶(γ-GT),谷胱甘肽S-转移酶(GST),胞液和膜性酪氨酸蛋白激酶(c-TPK,m-TPK)有不同程度的逐步升高,直至16周(除c-TPK在第12周活力最高外),而分化指标精氨酸酶(AGN)则明显降低,如在诱癌开始的同时给予全反式维甲酸(RA)连续16周则可延缓γ-GT、GST和两种TPK的升高和AGN的降低,这种作用并非RA本身对酶活力的影响,而是RA阻断肝癌发展的结果。
During the development of induced rat hepatocarcinoma by N-nitrosodiethylamine(DEN), the liver proliferative indexes including γ-glutamyltranspeptidase(γ-GT), glutathione Stransferase (GST), cytosolic and membranous tyrosine protein kinase (c-TPK, m-TPK) were gradually increased in various degrees up to 16 weeks,except c-TPK was highest in 12th week of carcinogenesis, and the liver differentiative index, arginase, was decreased significantly. If all-trans retinoic acid (RA) was administrated at the beginning of liver cancer induction with DEN and prolonged for 16 weeks, the increase of γ-GT, GST and both TPKs as well as the decrease of AGN were all slowed down. These effects were not caused by RA itself acting directly on enzyme activities,but were due to the blocking effect of RA on the development of liver carcinogenesis.
基金
卫生部八五攻关
CMB基金
关键词
维甲酸
肝癌
亚硝胺
Retinoic acid, Induced rat hepatocarcinoma,γ-Glutamyl transpeptidase, Tyrosin protein kinase, Arginase