摘要
本实验用乌拉坦麻醉的大鼠，探讨了下丘脑室旁核（ＰＶＮ）注射神经降压素（ＮＴ）对胃酸分泌的影响及其机制。结果表明，ＰＶＮ注射微量ＮＴ后，胃酸排出量呈剂量依赖性减少，此效应可被侧脑室内预先注射酚妥拉明所阻断，但不能被螺哌啶酮阻断、双侧颈迷走神经切断后，ＰＶＮ注射ＮＴ对胃酸排出量无明显影响。这提示，ＰＶＮ注射ＮＴ对大鼠胃酸分泌的抑制作用，可能与该处α－受体的激活有关，并通过迷走神经所中介。
Effects of microinjection of neurotensin (NT) into the hypothalamic paraventricular nucleus (PVN) on gastric acid secretion were investigated in urethane-anesthetized rats. The results were as follows: NT microinjection into PVN produced a dose-dependent decrease in gastric acid output (GAO); this inhibitory effect of NT was completely blocked by icv pretreatment with the α-adrenergic receptor antagonist phentolamine or after bilateral cervical vagotomy, suggesting that the effect may be related with activation of α-adrenergic receptors in the nucleus and mediated by vagal nerves.
出处
《生理学报》
CAS
CSCD
北大核心
1996年第2期185-189,共5页
Acta Physiologica Sinica
关键词
胃酸分泌
下丘脑室旁核
神经降压素
hypothalamic paraventricular nucleus
neurotensin
gastric acid secretion
phentolamine
vagotomy
