牛膝正丁醇萃取物对小鼠繁殖性能的影响

Effects of n-Butanol extract from Achyranthes bidentata on reproductive performance of mice

用不同剂量(0.5,2.0,4.0 g/kg)牛膝正丁醇萃取物给配对前的成年小鼠连续灌喂15 d,检测部分雄鼠精液品质、睾丸发育情况和内脏器官;同时在雌、雄小鼠合笼后观察小鼠妊娠及胚胎发育情况,以探讨牛膝正丁醇萃取物对成年小鼠繁殖性能的影响。结果表明,牛膝正丁醇萃取物不能明显干扰小鼠的繁殖性能,小鼠可以正常发情、妊娠,且胎儿发育正常,仅4.0 g/kg剂量处理组母鼠的胎仔数与其他各组相比差异显著(P<0.05)。2和4g/kg灌喂剂量可引起小鼠脾脏、肝脏、肾脏出现急性炎症反应。

In order to study the reproductive effects of n-butanol extract from Achyranthes bidentata on premarital mice,the research observed testis ,sperm quality and viscera of male mice ,as well as Pregnancy and fetuses of female mice after n-butanol extract from A. bidentata （0.5,2.0,4.0 g/kg） po for 15 d in premarital mice. The results showed that it had no significant antifertility action in females and males,except that viable fetuses per pregnant mouse in group Ⅰ （4.0 g/kg） was significantly different from that of the control mice （P〈0.05）. Meanwhile, significant pathological changes were found in the liver,spleen and kidney in the n-butanol extract of achyranthes bidentata supplementation when the dosage was 2.0 g/kg and 4.0 g/kg.