赛庚啶治疗抗精神病药物所致静坐不能的疗效对照分析

A controlled analysis of the efficacy of akathisia caused by antipsychotic drugs

目的探讨赛庚啶治疗抗精神病药所致静坐不能的疗效和安全性。方法将80例出现静坐不能的患者随机给予赛庚啶、心得安治疗16天。采用Barnes评定量表(BAS)、阴性症状量表(SANS)及阳性症状量表(SAPS),在治疗前及治疗后第4、8、12及16天分别评定疗效,并采用不良反应量表(TESS)在治疗前及治疗后第8及第16天分别评定不良反应。结果两组治疗后第16天与治疗前的BAS、SANS、SAPS评分比较,有显著性或非常显著性差异;治疗后第8天、12天,BAS评分比较有显著性及非常显著性差异;心得安和赛庚啶的有效率分别为85%、87.5%,疗效无显著性差异;TESS评定显示,赛庚啶组不良反应少于心得安组。结论赛庚啶治疗静坐不能疗效好、起效快,不良反应较心得安轻微。

Objective To explore the curative effect and safety of akathisia caused by antipsychotic drugs. Methods The 80 patients of akathisia were treated with eyproheptadine and propranolol of for 16 days respectively. The curative effects were evaluated by BAS, SANS and SAPS, before the treatment and on the 4th, 8th, 12th,and 16th day after the treatment separately. The side-effects were evaluated by TESS before and after 8 days and 16 days of the treatment. Results By comparing the BAS ,SANS and SAPS scores of these two groups before and after 16 day＇s treatment,we found that the curative effeets had a difference between remarkable or highly salient. The BAS scores had a difference after 8 day＇s and 12 day＇s treatment were also of great notability. The effective rates of propranolol and cyproheptadine were 85% and 87. 5% respectively, and the difference of curative effects between them is of no significance. The TESS evaluation showed that the side-effects were less than that of propranolol. Conclusions The cyproheptadine therapy is particular effect and could produce an instant effect against akathisia;furthermore ,its side-effect is also milder than that of propranolol.