摘要
一氧化氮是一种无机自由基气体,作为细胞内生物信使的作用正日益受到关注。卵巢是雌性动物的重要器官,NO作为一种较小的生物活性分子,可自由穿过细胞膜以相对特异的方式调控卵巢内多种细胞的生理功能。本文探讨了NO的主要作用机制,NO通过环鸟苷酸(cGMP)途径,及多种非cGMP依赖途径来调节卵巢中功能蛋白,如芳香化酶、抑制素、LH受体、环氧化酶及叉头螺旋转移因子(FOXO蛋白)的基因转录、mRNA翻译和相关蛋白的生成,为NO在畜牧生产的实际应运提供理论依据。
Nitric oxide is an inorganic free radical gas. There is an increasing interest in NO as a biological messenger in many fields of life science. Ovary is an important organ in the female animal. NO as a small molecule can freely diffuse through membranes and mediate multiple physiological functions in the ovary. The tracks are very complex with NO as cellular signal. This report reviewed the mechanisms of NO and the influence of NO on expression of functional proteins, such as aromatase, inhibin, LH-receptor, cyclooxyenase, and FOXO transcriptional factors in the ovary.
出处
《家畜生态学报》
2006年第2期92-96,共5页
Journal of Domestic Animal Ecology
基金
国家重点基础研究发展规划项目(973计划
2004CB117500)
南京农业大学高层次人才引进基金(804002)资助
关键词
NO
卵巢
功能蛋白
基因表达
细胞信使
NO
ovary
functional protein
altered gene expression
cell signal