一氧化氮对动物卵巢细胞中功能蛋白基因表达的调节

Regulation of Functional Proteins by Nitric Oxide in the Ovary

一氧化氮是一种无机自由基气体,作为细胞内生物信使的作用正日益受到关注。卵巢是雌性动物的重要器官,NO作为一种较小的生物活性分子,可自由穿过细胞膜以相对特异的方式调控卵巢内多种细胞的生理功能。本文探讨了NO的主要作用机制,NO通过环鸟苷酸(cGMP)途径,及多种非cGMP依赖途径来调节卵巢中功能蛋白,如芳香化酶、抑制素、LH受体、环氧化酶及叉头螺旋转移因子(FOXO蛋白)的基因转录、mRNA翻译和相关蛋白的生成,为NO在畜牧生产的实际应运提供理论依据。

Nitric oxide is an inorganic free radical gas. There is an increasing interest in NO as a biological messenger in many fields of life science. Ovary is an important organ in the female animal. NO as a small molecule can freely diffuse through membranes and mediate multiple physiological functions in the ovary. The tracks are very complex with NO as cellular signal. This report reviewed the mechanisms of NO and the influence of NO on expression of functional proteins, such as aromatase, inhibin, LH-receptor, cyclooxyenase, and FOXO transcriptional factors in the ovary.