衡阳地区支原体临床分离株对抗生素耐药性监测

Surveillance of Antibiotic Resistance of Mycoplasma Isolated From Clinical Samples in Hengyang

目的比较四环素类、大环内酯类和喹诺酮类三类抗菌药物对解脲脲原体(Uu)和人型支原体(Mh)的抗菌作用,为临床用药提供参考依据。方法采用直接肉汤药盘法测定了临床标本中195株Uu和118株Mh对三类抗菌药物中的8种抗生素的敏感性。结果195株Uu对四环素、多西环素、米诺环素、罗红霉素、阿齐霉素、交沙霉素、氧氟沙星、司帕沙星的敏感率分别为21.0%、48.2%、39.5%、79.0%、88.7%、74.9%、28.2%和64.6%。118株Mh对四环素、多西环素、米诺环素、罗红霉素、阿齐霉素、交沙霉素、氧氟沙星、司帕沙星的敏感率分别为5.1%、33.9%、26.3%、0.0%、0.0%、89.8%、70.3%和64.4%。960例混合感染的Uu+Mh,对交沙霉素最敏感(79.2%)。结论泌尿生殖道支原体的耐药性监测对指导临床治疗具有重要意义。

Objective To determine the susceptibility of clinical Ureaplasma urealyticum （Uu） and Mycoplasma hominis （Mh） isolates to tetracycline, macrolide and quinolone and to provide experimental data for clinical therapy. Methods The direct broth dish method was used for susceptibility testing of 195 isolates of Uu and 118 isolates of Mh with 8 antimicrobial agents. Results For the 195 isolates of Uu the percentage of susceptibility to tetracycline was 21. 0 %, to doxycycline was 48.2%, to minocycline 39.5%, to roxithromycin 79.0%, to azithromycin 88.7%, to jossamycin 74.9%, to ofloxacin 28.2 % and to sparfloxacin 64.6 % ; and for the 118 isolates of Mh was 5.1%, 33.9 %, 26.3 %, 0.0 %, 0.0 %, 89.8 %, 70. 3 % and 64.4 % respectively. The most susceptible antimicrobial agent to both Uu and Mh from 960 mixed infected patients was jossamycin （79.2 % ）. Conclusion Susceptibility monitoring of urogenital mycoplasma periodically is important in selection of clinical drug treatment.