氨基胍和维生素C对糖尿病大鼠肾功能的保护作用

Protective Effect of Aminoguanidine and Vitamin C on Renal Function of Streptozotocin-Induced Diabetic Rats

目的观察氨基胍、维生素C对糖尿病大鼠肾脏的保护作用。方法利用链脲佐菌素腹腔注射法诱导建立Ⅰ型糖尿病大鼠模型,将实验用SD大鼠随机分为正常对照组、糖尿病组、氨基胍治疗组、维生素C治疗组、维生素C和氨基胍联合治疗组。治疗16周。观察治疗期间及治疗后大鼠的一般状况、血糖、尿素氮、血肌酐,内生肌酐清除率、24h尿蛋白排泄率。结果①造模组大鼠均出现肾脏功能损害;②氨基胍、维生素C对血糖无影响,但能改善基本状况,降低糖尿病大鼠的尿素氮、血肌酐、24h尿白蛋白排泄率,增加内生肌酐清除率;③两种药物联合用药具有协同作用。结论氨基胍、维生素C无降糖作用,但具有确切的肾脏保护作用,联合用药有协同作用。

Objective To observe the effect of aminoguanidine and vitamin C on renal function of streptozotocin- indiabetic rats. Methods Diabetic nephropathy rat models were induced by intraperitoneal injection of streptozotocin （STZ）. Rats were allocated to normal control group, model group, vitamin C group, aminoguanidine group, and vitamin C and arninoguanidine combined group and received the treatment for a 16 - week period. During and after the treatment, the general status, blood glucose levels, blood urea nitrogen, serum creatinine, urinary albumin excretion rate within 24 - hour, and clearance rate of creatinine were monitored. Results Diabetes rnellitus and renal function lesion occurred in all the four DM model groups. Aminoguanidine and vitamin C had no effect on the blood glucose levels, but improved the general status, decreased blood urea nitrogen, serum creatinine, and urinary albumin excretion; increased creatinine clearance. Combined both arninoguanidine and vitamin C shewed a synergic action. Conclusion Aminoguanidine and vitamin C do not affect hyperglycemia but protect the renal function of model animals; and combination of both drugs demonstrates synergic activity.