枪击环境对大鼠胃电节律及胃粘膜损伤的影响

Effects of pistol shot sound environment on gastric motility and mucosal lesion in rats

目的:探讨战争环境应激状态下对大鼠胃电节律及胃粘膜的损伤,为预防战争应激环境对胃功能的损害提供科学依据。方法:将SD雄性大鼠60只,随机分成两组:Ⅰ组为枪击音应激组;Ⅱ组为空白对照组。并且随机将两组又各分为五个亚组,即1 d、3 d、5 d、7 d和14 d组。各亚组最终随机分为两部分,在应激条件下不同的时间内检测大鼠胃电变化, 并对胃粘膜的损伤情况进行分析处理,观察胃粘膜的病理变化。结果:随着应激时间的不断延长,胃功能变化呈现抑制状态,胃粘膜的损伤和病理变化愈加明显。结论:战争环境应激对胃电节律及胃粘膜可造成不同程度的影响和损伤,随着应激时间越长,损伤越严重。

Objective： To study the effects of gastric motility and mucosal lesion on stress under fighting environment. Methods： 60 SD rats were randomly divided into two groups, pistol shot sound - stress group （stress group, n = 30） and control group （n = 30）, and then each group was randomly divided five subgroups, that is, 1d, 3d, 5d, 7d and 14d group （n = 6）. Under pistol shot sound stress environment, the changes of gastric electrical activity and mucosal lesion were observed at different time. Results： As the stress time continued, the gastric electrical activity became inhibited and the lesion and pathological changes of gastric mucosa became gradually obvious. Conclusion： The pistol shot sound stress environment can affect the gastric motility and result in mucosal lesion, the longer the stress time is, the more severe the lesion is.