羟乙葛根素对β肾上腺素受体的阻断作用

The effect of hydroxyethylpuerarin on β-adrenergic receptors

目的观察异黄酮类化合物羟乙葛根素对肾上腺素受体的作用。方法分别利用离体家兔血管和离体蛙心观察羟乙葛根素对α,β肾上腺素受体的作用。结果羟乙葛根素对去甲肾上腺素引起的离体血管的收缩作用影响不明显,但可以使异丙肾上腺素兴奋离体蛙心的张力曲线幅度降低,频率变慢,与普萘洛尔具有相同的作用。结论羟乙葛根素可阻断β肾上腺素受体,但对α肾上腺素受体作用不明显。

Purpose Hydroxyethylpuerarin （compound N-2035 ） is modified in structure from puerarin which was extracted from Chinese traditional medicinal plant, R. Puerariae. This study is to investigate the effect of hydroxyethylpuerarin on adrenergic receptor. Methods The models of isolated rabbit aortic strips and isolated hearts were used to investigate the effect of hydroxyethylpuerarin on α and β-adrenoceptors. Results Hydroxyethylpuerarin decreased the ranges of heart-tension curves and made the frequency slow. These effects were similar to propranolol. Hydroxyethylpuerarin could not obviously inhibit the contraction of the aortic strips induced by noradrenaline. Conclusion Hydroxyethylpuerarin can block β-adrenoceptor on myocardium but has no obvious effect on α-adrenoceptor on vessels.