摘要
目的应用小鼠肿瘤模型,通过血管内皮细胞生长因子表达肿瘤微血管密度,了解血管抑素抑制肿瘤血管新生。方法免疫组化测定血管内皮细胞生长因子,通过肿瘤微血管密度表达肿瘤血管生长的情况,探讨肿瘤血管新生发生的可能机制。结果血管内皮细胞生长因子在肿瘤中的表达较少,主要表达在内皮细胞中。结论血管内皮细胞生长因子可以表达肿瘤血管密度,证明血管抑素可以抑制肿瘤血管新生。
Objective Applicating for the mice tumor model, we has examined VEGF for expressing MVD. Methods The VEGFdetermined by immunohistochemistry express MVD to explore mechanism in the course of anti-angiogenesis. Results VEGF expression is higher in endothelial cell than in tumor. Conclusion VEGF can express MVD in tumor. Our findings indicate that AS may play an important role in prohibite angiogenesis.
出处
《中国实验诊断学》
2006年第6期596-598,共3页
Chinese Journal of Laboratory Diagnosis
基金
吉林省科委科研基金资助(990564)
