原发性甲状腺功能减退性垂体增生的诊断和处理

Diagnosis and treatment of pituitary hypothyroidism-associated TSH-secreting pituitary hyperplasia

目的探讨原发性甲状腺功能减退性垂体增生的诊断和处理。方法回顾性分析6例确诊病人的临床资料。结果根据临床表现、内分泌检查和MRI表现可以明确诊断原发性甲状腺功能减退性垂体增生；甲状腺素试验性替代治疗2～4个月，甲状腺功能减退症状消失，血清TSH和PRL水平正常，垂体恢复正常大小。结论根据临床症状、内分泌检查和MRI表现完全可以明确诊断原发性甲状腺功能减退性垂体增生；甲状腺素试验性替代治疗是原发性甲状腺功能减退性垂体增生有效的治疗手段。

Objective To discuss the diagnosis and management of pituitary hyperplasia due to primary hypothyroidism. Methods Six cases were studied retrospectively. Results According to clinical manifestations endocrine examination and MRI, pituitary hyperplasia due to primary hypothyroidism could be diagnosed. After two to four months thyroxine substitution therapy, the manifestations of hypothyroidism disappeared, TSH and PRL became normal, pituitary gland recovered to normal size. Conclusion According to clinical manifestatiom endocrine examination and MRI, pituitary hyperplasia due to primary hypothyroidism could be diagnosed. Thyroxine substitution therapy was an effective therapy to primary hypothyroidism associated pituitary hyperplasia.