胸腺五肽对严重烧伤病人免疫调节作用的研究

Study on the regulating effect of Thymopentin on immune system of severe burned patients

目的研究胸腺五肽(Thymopentin,TP-5)对烧伤病人T淋巴细胞亚群及NK细胞的影响。方法对烧伤患者进行双盲随机对照临床研究。检测治疗组(20例)和对照组(20例)病人伤后第2、5、10、17、22天外周血T淋巴细胞亚群及NK细胞,治疗组病人从伤后第2天起接受TP-5治疗,1 mg/d,肌肉注射,疗程20 d;对照组不给予TP-5。结果烧伤后第2天二组病人T淋巴细胞及NK细胞无显著性差异(P>0.05);烧伤5、101、7、22天后二组病人T淋巴细胞总数差异显著(P<0.05),对照组CD8+细胞显著高于治疗组(P<0.01),对照组CD4+/CD8+;比值显著低于治疗组(P<0.01);治疗组NK细胞在烧伤51、0、17、22天后均高于对照组(P<0.05)。结论胸腺五肽可作为一种良好的免疫调节剂明显提高和改善严重烧伤患T淋巴细胞及NK细胞功能。

Objective To probe the changes of T-lymphocytes and NK cells of severe burned patients. Methods The doubleblind, controlled design clinical trial was conducted. Forty severe bum patients were enrolled in this study and randomly divided into TP-5 treated group（ n = 20） and control group（ n = 20）, T-lymphocytes NK cells were in peripheral blood were measured at 2,5,10, 17,22day after bum. TP-5 was administered by i. m in the dose of 1 mg/d in TP-5 group for 20 days, while TP-5 was not used in the control group. Results The numbers of T-lymphocytes and NK cells in two group of patients were not significantly different on the 2^nd day after bum（ P 〉 0.05）. On 5,10,17,22 day after bum, the total numbers of T-lymphocytes in two groups of patients were significantly different（ P 〈 0.05）. The number of CD8^＋ cells was higher in control group than in Tp-5 group（ P 〈 0.01 ） ; the value of CD4^＋/CD8^＋ was obviously lower in the control group than in Tp-5 group（P 〈0.01） and the content Of NK cells was higher in TP- 5 group than in control group on 5,10,17,22 day after bum（ P 〈 0.01）. Conclusion As a good immunomodulating medicine, TP- 5 could improve and enhance the function of T-lymphocytes and NK cells in severe bum patients.