非小细胞肺癌中DPC4基因的表达及意义

Significance of the Expression of DPC4 Gene in Non-small Cell Lung Carcinoma

目的探讨DPC4(deleted in pancreatic carcinoma locus 4,DPC4)基因在非小细胞肺癌(non-small cell lung car-cinoma,NSCLC)中的表达及意义。方法利用免疫组织化学S-P法检测52例NSCLC组织、19例相应的癌旁正常肺组织中DPC4的表达。结果DPC4在肺癌原发灶中的阳性表达率为63.5%(33/52),与癌旁正常肺组织中的阳性表达率89.5%(17/19)相比,DPC4阳性表达水平显著降低,差别有显著性意义(P<0.05);DPC4与组织学类型、肿瘤细胞分化程度无关(P>0.05),但与淋巴结转移显著相关(P<0.05)。结论DPC4的低表达可能是肺癌发生过程的早期事件,并可促进肺癌的淋巴结转移。

Objective To study the expression of DPC4（deleted in pancreatic carcinoma locus 4, DPC4）in non-small cell lung carcinoma. Methods The expression of DPC4, was detected in 52 cases with primary NSCLC and 19 adjacent normal lung tissues by using immunohistochemistrical S-P method. Results Positive expression rate of DPC4 in primary lung cancer tissues was 63.5% （33/52）,compared with the positive rate 89.5% （17/19）in adjacent normal lung tissues, the DPC4 expression level apparently degraded and there was significant differentiation（P 〈0.05）. The positive expression of DPC4 had no correlation with tissue types and cellular differentiation（P〉0. 05）, but it was closely associated with lymph node metastasis（P 〈0. 05）. Conclusion The low expression of DPC4 could be an early event during the course of the NSCLC＇s formation. Simultaneously,it also promoted lymph node metastasis