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Apoptosis induced by short hairpin RNA-mediated STAT6 gene silencing in human colon cancer cells 被引量：8

Apoptosis induced by short hairpin RNA-mediated STAT6 gene silencing in human colon cancer cells
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摘要 Background The relationship between signal transduction and tumors has become one of the loci in cancer research. Signal transducer and activator of the transcription 6 （STAT6） signaling pathway is found to be activated in some cancer cells. But the function of the pathway in cancer cells is unknown. This study was undertaken to investigate the effect of the Stat6 signaling pathway on apoptosis in human colon cancer cells （HT-29 cells） and the possible mechanism of Stat6 by RNA interference techniques. Background The relationship between signal transduction and tumors has become one of the loci in cancer research. Signal transducer and activator of the transcription 6 （STAT6） signaling pathway is found to be activated in some cancer cells. But the function of the pathway in cancer cells is unknown. This study was undertaken to investigate the effect of the Stat6 signaling pathway on apoptosis in human colon cancer cells （HT-29 cells） and the possible mechanism of Stat6 by RNA interference techniques.
作者 ZHANG Ming-sheng ZHOU Yun-feng ZHANG Wen-jie ZHANG Xiao-lian PAN Qin JI Xue-mei LUO Zhi-guo WU Jian-ping
机构地区 Department of Cancer Radio-Chemotherapy Department of Surgery Department of Immunology
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2006年第10期801-808,共8页 中华医学杂志（英文版）
基金 This study was supported by grants from the National Science Foundation of China (No. 30470981) and the National Science Foundation of Hubei Province (No. 2005ABA103).
关键词 RNA interference short hairpin RNA signal transducer and activator of transcription 6 TUMOR APOPTOSIS RNA interference short hairpin RNA signal transducer and activator of transcription 6 tumor apoptosis
分类号 R735.35 [医药卫生—肿瘤]
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参考文献10

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Chinese Medical Journal
2006年 第10期

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