常见念珠菌属的临床分布及对抗真菌药物敏感性研究

Distributive Properties and Susceptibility of Clinical Candida spp Isolates to Antifungal Agents

目的研究念珠菌属的临床分布及其对6种抗真菌药物的敏感性。方法对264株念珠菌属的临床分布进行分析,同时研究264株念珠菌属对两性霉素B、制霉菌素、氟康唑、咪康唑、克霉唑、酮康唑的敏感性。结果264株念珠菌属中,以白色念珠菌最常见占62.5%,其次为热带念珠菌占20.8%、光滑念珠菌占12.5%、近平滑念珠菌占1.9%、其他念珠菌占2.3%;念珠菌属感染的主要部位为肺、泌尿道、消化道;药物敏感试验显示:念珠菌属对制霉菌素、两性霉素B、氟康唑敏感性最高,对唑类药物存在不同程度的耐药。结论应加强对念珠菌属的鉴定及药物敏感性的检测,以指导临床抗感染治疗合理选择药物。

OBJECTIVE To study the distributive properties and susceptibility of yeasts to six antifungal agents. METHODS To analyze the distributive properties of 264 clinical Candida spp isolates and study the susceptibility to amphotericin B, nystatin, fluconazole, ketoconazole, miconazole and clotrimazole. The susceptibility of yeasts was tested according to the National Committee for Clinical Laboratory Standards guideline（NCCLS M27-A2）. RESULTS Strains of Candida albicans were the most frequent organism isolated accounted/or 62.5% of all the isolates. C. tropicalis, C. glabrata, and C. parapsilosis accounted for 20. 8%, 12. 5%, and 1.9%, the others accounted for only 2.3%. The main infected organs were lungs, urinary tract, and digestive tract; the susceptibility tests showed strains of Candida spp to nystatin, amphotericin B, and fluconazole were more active than to the other antifungal agents. The resistance to triazole antifugal agents could be shown. CONCLUSIONS We should strengthen the diagnosis of Candida spp and strengthen the surveillance on susceptibility of clinical isolates Candida spp so as to help the doctors choose the antifungal agents reasonably.