泌尿生殖道支原体感染及耐药性

Infection Status and Drug-susceptibility Analysis of Mycoplasma Strains Isolated from Genitourinary Tract

目的探讨泌尿生殖道支原体感染的现状及耐药性,为临床医师合理用药提供依据。方法应用法国Bio-Merieux生产的IST试剂盒进行支原体培养及药敏试验,并分析结果。结果312例疑似非淋菌性尿道炎(NGU)患者中,128例支原体培养阳性,阳性率为41.0%;其中,解脲脲支原体(Uu)占71.9%;人支原体(Mh)占2.3%;Uu+Mh阳性者占25.8%;药敏结果表明:支原体对9种抗菌药物耐药率最高的是红霉素(58.7%)、环丙沙星(50.0%)、氧氟沙星(41.3%);耐药率较低的药物为普那霉素(3.3%)、交沙霉素(5.4%)、多西环素(7.6%)。结论泌尿生殖道支原体感染主要以Uu发病率最高,对支原体感染治疗应根据药敏结果合理使用抗生素,目前可首选交沙霉素进行治疗。

OBJECTIVE To investigate the infection status and drug resistance of Mycoplasma strains isolated from genitourinary tract. METHODS The IST kit produced by Bio-Merieux was used to culture the Mycoplasma strains and to do drug susceptibility test. RFSULTS The Mycoplasma infection ratio was 41.0%, with Ureaplasma urealyticum（Uu） 71.9%, Mycoplasma hominis（Mh） 2.3%, and mixed infection 25.8%, respectively. The drug susceptibility test showed that drug resistance ratios were as follows： to erythromycin 58. 7%, ciprofloxacin 50. 0%, ofloxacin 41.3%, pristinamycin 3.3%, josamycin 5.4% and doxycycline 7.6%. CONCLUSIONS Mycoplasma infection in genitourinary tract is mainly due to Uu infection. We should rationally choose and use antibiotics according to the drug susceptibility, and josamycin is very effective.