直肠癌癌周组织ICAM-1、CEA和CD31的表达(英文)

The expression of ICAM-1,CEA and CD31 in peritumoral tissues of rectal cancer

目的:研究直肠肿瘤发生血管转移的机制。方法:选取8例直肠腺癌患者的癌周组织和淋巴结,6例正常人的直肠组织和淋巴结,用免疫组化sp法处理标本。结果:癌周直肠组织及癌周淋巴结中的血管内皮细胞内,均有ICAM1和CEA的强表达。癌周直肠组织中及癌周淋巴结中的血管内皮细胞内,均有CD31的表达;而正常对照组直肠组织和淋巴结中血管内皮细胞亦见CD31的表达,表达的强度相同。结论:研究表明ICAM1和CEA在癌细胞和内皮细胞之间可能起到一定的粘附作用,而CD31在癌细胞和内皮细胞之间作用还不是十分清楚。

Objective：In order to study mechanism of hematogenous metastasis of rectum cancer.Methods：8 specimens of human rectum cancer and 6 specimens of rectum in normal human were examined.The immunohistochemical SP method was employed in study of the expression of ICAM1,CEA and CD31 in the peritumoral rectum tissues and lymphy nodes.Results：The intercellular role in the adhesion molecule-1（ICAM-1）and carcinoma embryonic antigen（CEA） were expressed on the vascular endothelial cells of peritumoral rectum tissues and peritumoral lymph nodes in the rectum cancer.CD31 are expressed on the vascular endothelial cells of rectum tissues from normal human with the same intensity of cancer peritumoral rectum tissues.Conclusion：This study showed that ICAM-1 and CEA seemed to play a stable role in the adhesion effect between cancer cells and endothelial cells.It is not clear whether CD31 plays a role in the interaction between cancer cells and endothelial cells.