硫酸镁辅助治疗难治性癫痫研究(附48例分析)

Study of the Magnesium Sulfate in the Adjuvant Therapy of the Intractable Epilepsy: A Report of 48 Cases

目的探讨硫酸镁辅助治疗难治性癫痫的剂量、方法及疗效。方法 72例患者,随机分为治疗组48 例和对照组24例,对照组给予常规抗癫痫药物丙戊酸钠、γ-氨基丁酸治疗。治疗组在此基础上给予25％硫酸镁5 ml 静脉滴注,或给予16．5％硫酸镁5ml口服。结果治疗组与对照组间疗效比较差异有非常显著性意义(u=4．11,P< 0．01)。结论硫酸镁联合一线抗癫痫药治疗顽固性癫痫的方法简单易行,具有良好效果。

Objective To explore the dosage, method and curative effect of the magnesium sulfate treating the intrac-table epilepsy. Methods 72 cases were divided into treatment group （48cases） and control group （24cases）. For those in the treatment group, on the basic of the routine antiepilepsy druge, either 5ml of 25% MgSO4 was administered by intravenous drip or 5ml of 16. 5%MgSO4 by oral intake once per day. For those in the control group, the rutine antiepilepsy drugs such as Sodium Valproate, r - Aminobutyie Acid were used. Results There is obvious difference between the treatment group and control group （ P 〈0. 05）. Conclusion Magnesium sulfate in conjunction with the antiepilepsy drugs is a simple and effective method for the treatment of the intractable epilepsy.