摘要
目的:观察芍药苷对东莨菪碱致小鼠记忆形成障碍、亚硝酸钠致记忆巩固障碍和乙醇致记忆再现障碍的影响。方法:采用小鼠跳台法和Y型迷宫法。结果:芍药苷7.5、15、30mg/kgiv3日对小鼠学习记忆功能有明显的促进作用,对东莨菪碱致小鼠记忆形成障碍、亚硝酸钠致记忆巩固障碍和乙醇致记忆再现障碍有明显的改善作用,且呈一定的剂量依赖关系。结论:芍药苷对东莨菪碱、亚硝酸钠和乙醇致小鼠记忆获得、巩固及再现障碍均有不同程度的改善作用。
To study the effects of paeoniflorin on learning and memory abilities. Methods： the step-down test and Y-maze test were adopted. Results： The results indicated that paeoniflorin （7.5,15,30mg/kg, iv x 3d） dose-dependently improved the impairment of memory acquisition, memory consolidation and memory retrieval induced by scopolamine, NaNO2 and alcohol in mice. Conclusion： Paeoniflorin can improve the impairment of memory acquisition, memory consolidation and memory retrieval induced by scopolamine, NaNO2 and alcohol in mice.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第1期23-25,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
芍药苷
学习记忆
跳台法
迷宫法
paeoniflorin
learning and memory ability
step-down test
Y-maze test
