阿托伐他汀对急性冠脉综合征患者血脂及C反应蛋白的影响

Clinical effect of atorvastalin treatment early on the serum lipid and C reactive protein in patients with acute coronary syndrome

目的:探索阿托伐他汀对急性冠脉综合征(ACS)患者高脂血症及C反应蛋白(CRP)的作用。方法:82例 ACS患者随机分为阿托伐他汀组和常规治疗组,分别在入院时、1周后及接受高脂餐负荷实验后检测CRP和血脂水平。结果:阿托伐他汀治疗组患者治疗后CRP及总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)水平显著降低 (P<0．01),餐后血浆TG、CRP较对照组显著降低(P<0．001,<0．01)。结论:短期阿托伐他汀治疗可有效降低 ACS患者血清中CRP、TG、LDL-C水平。

Objective： To investigate the levels of serum lipid, C reactive protein （CRP） in patients with acute coronary syndrome （ACS） and the effects of atorvastatin on levels of blood lipid and CRP. Methods： Total of 82 patients were divided into two groups randomly： control group and atorvastatin group. Blood lipid and CRP contents were measured on the admission, 1 week later and after a high-fat meal. Results：CRP, TC and LDL-C levels of patients were significantly decreased （P〈0.01 all） ; CRP and TG after a high-fat meal were also significantly decreased （P〈0. 01. 0, 001, respectively） in atorvastatin group. Conclusion： Short-term atorvastatin therapy can effectively lower CRP. TG and LDL-C levels in ACS patients.