复方甘草酸苷对慢性重症肝炎患者肝脏储备功能的影响

Effect of Compound Glycyrrhizin on Hepatic Function of Reserve in Patients with Chronic Fulminate Hepatitis

目的:了解复方甘草酸苷对慢性重症肝炎患者肝脏储备功能的影响。方法:100例慢性重症肝炎患者分为复方甘草酸苷组(治疗组50例。静滴复方甘草酸苷80 mL/d,连续60 d)和肝安组(对照组50例。静滴肝安250 mL/d,连续60 d);60d后检测两组肝功能指标及肝脏储备功能的变化。结果:治疗组肝脏储备功能较治疗前明显升高(P<0.05),与对照组比无统计学意义(P>0.05);两组肝功能指标均有改善(P<0.05)。结论:复方甘草酸苷能显著减轻肝脏损伤程度,提高其储备功能,且耐受性良好,无明显不良反应。

Objective： To understand the effect of compound glycyrrhizin on hepatic function of reserve in patients with chronic fulminate hepatitis. Methods： One hundren patients with chronic fulminate hepatitis were divided into treatment group（50 cases were injected chronic fulminate hepatitis of 80 mL iv. drip, once a day, 60 days continuously）and control group（50 cases were injected 15AA of 250 mL iv. drip, once a day, 60 days continuously）. The changes of the liver function indices and the hepatic function of reserve were detenninated 60 days after treatment. Results： Sixty days after treatment, the hepatic function of reserve in treatment group was higher（ P 〈 0.05）. There was no statistically significance in hepatic function of reserve in treatment group, compared with control group. The liver function indices between two groups were improved（P 〈 0.05）. Conclusion： The compound glycyrrhizin can greatly reduce the damage of liver,and raise the hepatic function of reserve. There is a good toleration, and no obvious side effects have been found.