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大鼠脑缺血/再灌注后TGF-β_1的表达 被引量：2

Expression of TGF-β_1 during reperfusion after middle cerebral artery occlusion in rat brain
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摘要 目的探讨大鼠脑缺血再灌注后转移生长因子β1(TGF-β1)在脑组织中的表达。方法采用线栓法制备大鼠局灶性脑缺血再灌注模型,通过免疫组化法检测TGF-β1的表达。结果TGF-β1在缺血再灌注3h开始表达,24h达高峰,持续至72h,72h后逐渐减弱。结论脑缺血后神经元的损伤修复与TGF-β1的表达密切相关,提示TGF-β1参与了神经元损伤的修复过程。 Objective To study the expression of transforming growth factor -beta 1 （ TGF -β1） at different time points of reperfusion after middle cerebral artery occlusion （MCAO） of rat brain. Methods The ischemia- reperfusion models of rat brain were made by immunohistoehemical technology. The expression of TGF-β1 in rat brain was observed. Rusuits The expression of TGF-β1 increased at 3 h of reperfusion reached its peak at 24 h and still elevated at 72 h, than decreased after 72 h. Conclusions The injury, and repair of nervous cells after cerebral isehemia have correspondences with the expression of TGF-β1, so that TGF-β1 participated in the process of repairment of the injuried nervous cells.
作者 朱国俊 吴云志 於孝奎 潘亚强 吴小伟
机构地区 江苏宜兴武警 南京医科大学第二附属医院神经外科
出处 《临床神经外科杂志》 CAS 2006年第2期60-61,共2页 Journal of Clinical Neurosurgery
关键词 缺血再灌注 转移生长因子(TGF—β1) 表达 reperfusion after cerebral isehemia transforming growth factor -beta 1 （ TGF-β1 ） expression
分类号 R575.2 [医药卫生—消化系统] R364.4 [医药卫生—病理学]
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共引文献5

同被引文献18

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临床神经外科杂志
2006年 第2期

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