复杂性肾结石感染的菌谱、耐药谱分析

Bacterial pattern and drug resistance pattern of complex renal calculi

目的了解复杂性肾结石合并感染的比率、菌种分布及对抗生素的耐药性和敏感性。方法回顾性分析复杂性肾结石患者891例相关资料,统计术前中段尿细菌培养和药物敏感试验结果。结果891例尿液标本中,标本阳性率49.27%(439/891),检出细菌453株,其中革兰阳性菌32.45%(147/453),革兰阴性菌60.26%(273/453),真菌7.28%(33/453),药敏试验结果不同于菌种抗菌谱,有明显差异。结论复杂性肾结石合并感染比率高,菌种分布广,不同菌种对抗生素的敏感性差异明显,提示临床应根据不同菌种和药敏试验结果合理选择抗生素。

Objective To study the midstream urine positive ratio of bacterial infection,the bacterial distribution and the drug resistance and sensitivity of the pathogens in patients who suffered from complex renal calculi. Methods A Retrospectively clinical study was performed in 891 patients with complicated renal calculi. The distribution and constitution of the pathogens and the drug resistance of the commonly use antibiotics were investigated. Results There were 49.27% （439/891） of positive midstream urine culture rate, and 453 strains bacterium induing, Gream-negative organisms 60.26% （273/453） ,Gream-positive oragaisms 32.45% （ 147/453 ） and fungi 7.28% （ 33/453 ） respectively. The resistant rates of pathogens to the commomly used anfimicrobials were higher than those of rarely used antimicrobial agents. Conclusion The complex renal calculi has the higher incidence of positive lacterial infection,the wider distribution of pathogens and the more difference in sensitivity to antibioties.