摘要
目的观察卡维地洛治疗慢性心力衰竭的疗效。方法选择慢性心力衰竭(CHF)患者共40例,给予卡维地洛2.5mg,2次/d,每7～10d增加2.5mg;逐渐增加至患者最大耐受剂量(本组为10mg,2次/d)后维持用药2个月以上,观察用药前后心功能、心率及心律失常变化。结果心功能改善,射血分数(EF)增加,由34.6±11.0增至46.6±10.2(P<0.01),左心室收缩末期内径(LVESD)及左心室舒张末期内径(LVEDD)均缩小(P<0.01),总有效率90%;在心室率控制方面,由治疗前的平均心率(116.0±11.2)次/min降至治疗后(68.1±7.2)次/min(P<0.05)。结论提示CHF的治疗在常规利尿、扩血管、对因治疗基础上,加用卡维地洛会取得较好的效果。
Objective To observe the clinical influence of Carvedilod （ Luode ） on chronic heart failure （CHF）. Methods 40 eases of CHF taken earvedilod 2.5 rag,bid,for 7-10 days,and then added gradually to the maximum tolerated dose （ 10 mg one day）and kept this dose for more than 2 months. The heart function,heart rate and eardial arrhythmias were observed in all eases. Results Improvement of heart function ,the increase of ejection fraction （EF） （ from 34.6 ± 11.0 to 46.6 ± 10.2, P 〈 0.01 ）, and reduction of LVESD and LVEDD （ P 〈 0.01 ） were observed,with total effective rate 90% ;The average heart rate after treatment was lower than that before treatment[from （116.0± 11.2} bpm to （68.1 ±7.2） bpm,P〈0.05）. Conclusion The treatment of CHF would be more effective by application of earvedilol besides diuresis,dilation of blood vessel and at etiopathogenie treatment.
出处
《中国医药》
2006年第2期65-66,共2页
China Medicine
关键词
慢性心力衰竭
卡维地洛
心功能
Chronic heart failure
Carvedilod
Heart function
